中央研究院細胞與個體生物學研究所

姓名：周申如

職稱：副研究員

電話： 02-2789-9530

專長：Neural development,
developmental biology

Link：

研究人員 / 簡介

2019-	Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2011-2019	Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2002-2011,	Postdoctoral Research Fellow, Molecular Neurobiology Laboratory, Salk Institute, USA
2002,	PhD. Department of Molecular and Cellular Biology, Baylor College of Medicine, USA.

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哺乳動物神經發育實驗室

Figure1. Functional domains in the cerebral cortex are characterized by unique cytoarchitectures and patterns of gene expression.

Figure2. Developing a functional brain from the embryonic dorsal telencephalon.

The mammalian cerebral cortex is a remarkably complex organ responsible for the perception of sensory stimuli, the execution of motor actions, cognition and consciousness. It contains many neuronal cell types, and a substantial fraction of the more than 10 billion neurons in the human brain form 10¹³-10¹⁵ connections within the cortex and with other regions of the central nervous system. The generation of the variety of neuronal types and the establishment of proper connections are crucial for the function of cortex.

The cerebral cortex is comprised of several structural and functional domains, including the six-layered neocortex and the architecturally more simple and phylogenetically older cortices, including the paleocortex, which is predominantly the olfactory cortical structure, the piriform cortex; and the archicortex, which is predominantly the hippocampal formation. The neocortex is further patterned into specialized areas, including primary somatosensory, auditory and visual areas. Each of the primary sensory areas processes modality-specific sensory information relayed from the periphery via thalamocortical axon (TCA) inputs originating from the dorsal thalamus. Each of these functional domains in the cerebral cortex is characterized by unique cytoarchitecture, particular patterns of gene expression (as shown in Fig. 1), and specific sets of input and output processing networks.

The great majority of neurons that form each region of the cerebral cortex arise from one prominent continuous germinal zone, the ventricular zone in the dorsal telencephalon. Anatomically, the progenitors in the ventricular zone of the dorsal telencephalon appear uniform; however, they give rise to brain regions with different anatomies and neural connections. The fascinating question for us is how different cortical neurons are derived from the seemingly uniform progenitor population. It was shown previously that transcription factors that are expressed in graded patterns along the anterior-posterior and medial-lateral cortical axes control the location and size of primary sensory areas in the neocortex, and that TCA inputs play an instructive role in controlling area-specific gene expression.

The primary research interest of our laboratory is to understand the mechanisms controlling development of the cerebral cortex, with a particular focus on understanding how the uniform neuroepithelium of the embryonic dorsal telencephalon gives rise to specialized regions of the cortex (Fig. 2). Using a combination of genetic, embryological and molecular biology methods, we will explore how neuron diversity and the myriad of their connections are generated during development through the interplay of genetic programs intrinsic to the cortex and extrinsic mechanisms, such as neuronal inputs. Our long-term goals are to understand how changes in genes that regulate these processes lead to changes in cortical organization during evolution and disease.

姓名	職稱	電話	Email	備註
周申如	助研究員	02-2789-9530	schou@gate.sinica.edu.tw	1
王家芳	博士後研究員	2789-9531	cfwang@gate.sinica.edu.tw
馮佳	博士後研究員	2789-9531	emafengjia@gmail.com
牛振憲	研究助理	2789-9531	bullyzala@gmail.com
邢翔威	研究助理	2789-9531	dimars1000@hotmail.com
莊子慧	研究助理	2789-9531	h85055@gmail.com
溫孟璇	研究助理	2789-9531	mhwen@imb.sinica.edu.tw
黃一婷	研究助理	2789-9531	t726t726@gmail.com

著作目錄

Chou SJ, Wang C, Sintupisut N, Niou ZX, Lin CH, Li KC, Yeang CH. (2016) Analysis of spatial-temporal gene expression patterns reveals dynamics and regionalization in developing mouse brain. Sci Rep. 6:19274.
Zembrzycki A, Stocker AM, Leingärtner A, Sahara S, Chou SJ, Kalatsky V, May SR, Stryker MP, O'Leary DD. (2015) Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. Elife 4:e11416.
Hsu CL, Nam S, Cui Y, Chang CP, Wang CF, Kuo HC, Touboul J and Chou SJ. (2015) Lhx2 regulates the timing of beta-catenin-depedent cortical neurogenesis. Proc Natl Acad Sci U S A. 112(39):12199-204
Zembrzycki A, Perez-Garcia CG, Wang CF, Chou SJ and O’Leary DDM. (2015) Postmitotic regulation of sensory area patterning in the mammalian neocortex by Lhx2. Proc Natl Acad Sci U S A. 112 (21):6736-41.
Pao GM, Zhu Q, Perez-Garcia CG, Chou SJ, Suh H, Gage FH, O’Leary DDM and Verma IM. (2014) Role of BRCA1 in brain development. Proc Natl Acad Sci U S A. 111 (13):1371-80.
Huang TN, Chuang HC, Chou WH, Chen CY, Wang HF, Chou SJ and Hsueh YP. (2014) Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Nature Neuroscience. 17(2): 240-7.
Hou PS, Chuang CY, Kao CF, Chou SJ, Stone L, Ho HN, Chien CL and Kuo HC. (2013) LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of Pax6 and CER1. Nucleic Acids Research. 41(16): 7753-80.
Zembrzycki A, Chou SJ, Ashery-Padan R, Stoykova A and O’Leary DDM. (2013) Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits. Nature Neuroscience. 16(8):1060-7.
Chou SJ*, Babot Z*, Leingartner A, Studer M, Nakagawa Y and O’Leary DDM. (2013) Geniculocortical input drives genetic distinctions between primary and higher-order visual areas. Science. 340:1239-42. (*: equal contribution)
Chou SJ and O’Leary DDM. (2013) Role for Lhx2 in corticogenesis through regulation of progenitor differentiation. Molecular Cellular Neuroscience. 56: 1-9.
Li H*, Chou SJ*, Perez-Garcia CG, Hamasaki T, Gassmann M and O’Leary DDM. (2012) Neuregulin repellent signaling via ErbB4 funnels migrating GABAergic cortical interneurons from the ganglionic eminence through the forebrain. Neural Development. 7:10 (*: equal contribution)
Chou SJ, Peres-Garcia CG, Kroll TT and O’Leary DDM. (2009) Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Nature Neuroscience. 12:1381-1389.
O’Leary DDM, Chou SJ, Sahara S. (2007) Area patterning of the mammalian neocortex. Neuron. 56:252-269.
Armentano M*, Chou SJ*, Tomassy GS, Leingärtner A, O’Leary DDM and Studer M. (2007) COUP-TF1 regulates the balance of cortical patterning between frontal/motor and sensory areas. Nature Neuroscience. 10:1277‑1286 (cover article, *: equal contribution)
O’Leary DDM, Chou SJ, Hamasaki T, Sahara S, Takeuchi A, Thure, S, Leingartner A (2007). Regulation of laminar and area patterning of mammalian neocortex and behavioral implications. In: Development of the Cerebral Cortex. Novartis Foundation Symposium. G. Bock, H. Saunders, and J. Parnavelas, Eds.
Leingartner A, Thuret S, Kroll TT, Chou SJ, Leasure JL, Gage FH, O'Leary DDM. (2007). Cortical area size dictates performance at modality-specific behaviors. Proc Natl Acad Sci U S A. 104(10):4153-8.
Chou SJ, Hermesz E, Hatta T, Feltner D, El-Hodiri HM, Jamrich M, Mahon KA (2006). Conserved regulatory elements establish the dynamic expression of Rpx/HesxI in early vertebrate development. Dev Biol. 292(2):533-45

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